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Sperm DNA Fragmentation & Male Infertility Treatment | Bliss Fertility Kerala

  • Writer: Abhijith R
    Abhijith R
  • 10 hours ago
  • 4 min read
Specialist at Bliss Fertility Hospital explaining Sperm DNA Fragmentation diagnostic results for male infertility treatment.
Specialist at Bliss Fertility Hospital explaining Sperm DNA Fragmentation diagnostic results for male infertility treatment.

For many years, the conversation around infertility focused almost exclusively on the female partner. When the male partner was tested, a simple semen analysis was the only tool used to determine his reproductive health. However, many couples have faced the frustration of having a "normal" semen report but still failing to conceive or experiencing recurrent miscarriages. This is where a deeper understanding of male infertility treatment becomes essential, specifically focusing on a factor called Sperm DNA Fragmentation.


At Bliss Fertility Hospital, we go beyond the basics. As the best infertility hospital in Kerala, we provide advanced diagnostics to uncover the hidden barriers to fatherhood. Whether you are visiting our best IVF clinic in Trivandrum, searching for affordable IVF clinics in Kottayam, or seeking expert care at our affordable IVF clinics in Tirur, we are here to provide the answers you need.


What is Sperm DNA Fragmentation?



A standard semen analysis measures count, motility (movement), and morphology (shape). While these are important, they don't tell us about the quality of the genetic material carried inside the sperm. Sperm DNA fragmentation refers to breaks or lesions in the genetic material of the sperm.


According to research from the American Society for Reproductive Medicine (ASRM), high levels of fragmentation can prevent fertilization, lead to poor embryo development, and are a leading cause of early pregnancy loss. This is a critical area of study within advanced infertility care Trivandrum, as it explains why some couples fail to achieve success even with standard female infertility treatments.


Why Does DNA Fragmentation Happen?


Several factors can lead to increased DNA damage in sperm. Understanding these is a vital part of any male infertility treatment plan:


Oxidative Stress: The most common cause, often triggered by lifestyle factors like smoking, poor diet, or environmental pollutants.

Varicocele: Swollen veins in the scrotum that increase testicular temperature. You can read more about varicocele symptoms on the Mayo Clinic website.

Infections: Silent infections in the reproductive tract.

Age: While men produce sperm throughout their lives, DNA integrity can decline with age.


The Diagnostic Journey: Beyond the Standard Semen Analysis



When couples ask about the semen test price in Kerala, they are often looking for a basic count. However, at the best IVF center in Kerala, we recommend specialized DNA Fragmentation Index (DFI) testing for couples with unexplained infertility or repeated IVF failures.


Identifying high DFI allows our specialists to pivot the treatment strategy. For example, if the fragmentation is high, we might recommend moving from IUI vs IVF in Trivandrumdiscussions toward ICSI (Intracytoplasmic Sperm Injection) with specialized sperm selection techniques. In severe cases, we may bypass ejaculated sperm entirely and perform a sperm extraction procedure in Kerala to obtain healthier sperm directly from the source.


Advanced Solutions: PESA and TESA


When DNA fragmentation in ejaculated sperm is too high, the sperm found directly in the testes often has much lower levels of damage. This is where the surgical expertise of Bliss Fertility Hospital becomes a game-changer.


We offer specialised procedures such as:


PESA sperm retrieval: A simple, needle-based aspiration used to collect sperm from the epididymis.

TESA (Testicular Sperm Aspiration): Collecting sperm directly from the testicular tissue.


By using these methods, we can often find sperm with superior genetic integrity, significantly increasing the success rates of your IVF treatment in Kerala. We provide transparent information on the TESA cost in Kerala, ensuring that families can plan their journey without financial ambiguity.


Integrating Male and Female Care


At our fertility treatment hospital in Kerala, we believe in a balanced approach. While we address male factors, we simultaneously optimize the female partner’s health. This might involve ovulation stimulation treatment, Kerala to ensure high-quality eggs are available for the retrieved sperm.


By balancing female infertility treatments with expert male diagnostics, we reduce the overall cost of IVF in Kerala by maximizing the chances of success in the very first cycle. For those who wish to delay their journey, we also offer egg/sperm freezing in Kerala and provide clear guidance on the cryopreservation cost Kerala.


Serving Trivandrum, Tirur, and Kottayam


Bliss Fertility Hospital is proud to be a regional leader in male reproductive health across our specialized centers:


In Trivandrum: We provide the most advanced infertility care Trivandrum has to offer, featuring high-end andrology labs that specialize in DFI testing and micro-manipulation.

In Kottayam: As the best IVF clinic in Kottayam, we help local families understand that the male partner’s health is just as important as the female’s. We are recognized as one of the most affordable IVF clinics in Kottayam for comprehensive diagnostics.

In Tirur: We bring advanced surgical sperm retrieval to the Malabar region. Our center is known as one of the most reliable affordable IVF clinics in Tirur, ensuring that men in the area don't have to travel to major metros for world-class care.


Why Choose the Best IVF Hospital in Kerala?


Choosing Bliss Fertility means choosing a team that looks at the "hidden" details. We are the Best IVF hospital in Kerala because:


1. Specialised Andrology: Our labs are dedicated to the deepest levels of male fertility testing.

2. Surgical Expertise: We are leaders in PESA sperm retrieval and other extraction methods.

3. Transparent Pricing: From the semen test price Kerala to complex surgeries, our costs are clear.

4. Holistic Success: We integrate male infertility treatment with advanced female infertility treatments for a total care package.


Don't Settle for "Normal"


If you have been told your semen analysis is "normal" but you are still struggling to conceive, it is time to look deeper. Sperm DNA fragmentation could be the missing piece of your puzzle.


Visit Bliss Fertility Hospital, the best infertility hospital in Kerala. Whether you visit us inTrivandrum, Tirur, or Kottayam, our experts are ready to provide a comprehensive evaluation and a path toward Parenthood. Knowledge is power—let us help you understand your fertility at a genetic level.




Call Now


+91 62 62 62 32 62 (Kottayam & Maldives)






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